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3VYE

Human renin in complex with inhibitor 7

Summary for 3VYE
Entry DOI10.2210/pdb3vye/pdb
Related3VYD 3VYF
DescriptorRenin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-N-(3-methylbutyl)piperidine-3-carboxamide, ... (4 entities in total)
Functional Keywordsaspartyl protease, ras, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight75846.44
Authors
Takahashi, M.,Matsui, Y.,Hanzawa, H. (deposition date: 2012-09-24, release date: 2012-12-19, Last modification date: 2023-11-08)
Primary citationMori, Y.,Ogawa, Y.,Mochizuki, A.,Nakamura, Y.,Sugita, C.,Miyazaki, S.,Tamaki, K.,Matsui, Y.,Takahashi, M.,Nagayama, T.,Nagai, Y.,Inoue, S.,Nishi, T.
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors
Bioorg.Med.Chem.Lett., 22:7677-7682, 2012
Cited by
PubMed: 23122821
DOI: 10.1016/j.bmcl.2012.09.103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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