3V4J
First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G
Summary for 3V4J
Entry DOI | 10.2210/pdb3v4j/pdb |
Descriptor | DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION, 4-[methyl(nitroso)amino]benzene-1,2-diol, ... (4 entities in total) |
Functional Keywords | hydrolase, apobec3g, antiviral defense, host-virus interaction, metal-binding, nucleus |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9HC16 |
Total number of polymer chains | 2 |
Total formula weight | 48774.05 |
Authors | Shandilya, S.M.D.,Ali, A.,Schiffer, C.A. (deposition date: 2011-12-15, release date: 2012-02-01, Last modification date: 2023-09-13) |
Primary citation | Li, M.,Shandilya, S.M.,Carpenter, M.A.,Rathore, A.,Brown, W.L.,Perkins, A.L.,Harki, D.A.,Solberg, J.,Hook, D.J.,Pandey, K.K.,Parniak, M.A.,Johnson, J.R.,Krogan, N.J.,Somasundaran, M.,Ali, A.,Schiffer, C.A.,Harris, R.S. First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G. Acs Chem.Biol., 7:506-517, 2012 Cited by PubMed: 22181350DOI: 10.1021/cb200440y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
Download full validation report