3ULI
Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative
Summary for 3ULI
Entry DOI | 10.2210/pdb3uli/pdb |
Descriptor | Cyclin-dependent kinase 2, 1-(aminomethyl)-N-(3-{[6-bromo-2-(4-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]amino}propyl)cyclopropanecarboxamide (3 entities in total) |
Functional Keywords | azabenzimidazole derivative, phosphotransfer, complex with cyclin a or cyclin e, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 |
Total number of polymer chains | 1 |
Total formula weight | 34449.85 |
Authors | Larsen, N.A.,Tucker, J.A.,Wang, T. (deposition date: 2011-11-10, release date: 2013-08-14, Last modification date: 2024-02-28) |
Primary citation | Wang, T.,Block, M.A.,Cowen, S.,Davies, A.M.,Devereaux, E.,Gingipalli, L.,Johannes, J.,Larsen, N.A.,Su, Q.,Tucker, J.A.,Whitston, D.,Wu, J.,Zhang, H.J.,Zinda, M.,Chuaqui, C. Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKK epsilon kinases. Bioorg.Med.Chem.Lett., 22:2063-2069, 2012 Cited by PubMed: 22305584DOI: 10.1016/j.bmcl.2012.01.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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