3UFQ
Structure of rat nitric oxide synthase heme domain in complex with 6-(((3S,4S)-4-(((E)-5-(3-fluorophenyl)pent-4-en-1-yl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine
Summary for 3UFQ
Entry DOI | 10.2210/pdb3ufq/pdb |
Related | 3UFO 3UFP 3UFR 3UFS 3UFT 3UFU 3UFV 3UFW |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100262.97 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2011-11-01, release date: 2012-07-11, Last modification date: 2023-09-13) |
Primary citation | Huang, H.,Ji, H.,Li, H.,Jing, Q.,Labby, K.J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations. J.Am.Chem.Soc., 134:11559-11572, 2012 Cited by PubMed: 22731813DOI: 10.1021/ja302269r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.058 Å) |
Structure validation
Download full validation report