3UFA

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

Summary for 3UFA

Entry DOI	10.2210/pdb3ufa/pdb
Related PRD ID	PRD_000908
Descriptor	Serine protease splA, N-(3-carboxypropanoyl)-L-valyl-N-[(1S)-2-phenyl-1-phosphonoethyl]-L-prolinamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	chymotrypsin like fold, serine protease, extracellular protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Staphylococcus aureus
Cellular location	Secreted: Q2FXC2
Total number of polymer chains	2
Total formula weight	44872.28
Authors	Zdzalik, M.,Pietrusewicz, E.,Pustelny, K.,Stec-Niemczyk, J.,Popowicz, G.M.,Potempa, J.,Oleksyszyn, J.,Dubin, G. (deposition date: 2011-10-31, release date: 2013-01-23, Last modification date: 2014-03-05)
Primary citation	Burchacka, E.,Zdzalik, M.,Niemczyk, J.S.,Pustelny, K.,Popowicz, G.,Wladyka, B.,Dubin, A.,Potempa, J.,Sienczyk, M.,Dubin, G.,Oleksyszyn, J. Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus. Protein Sci., 23:179-189, 2014 Cited by PubMed: 24375505 DOI: 10.1002/pro.2403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation