3U6I

Crystal structure of c-Met in complex with pyrazolone inhibitor 58a

Summary for 3U6I

Entry DOI	10.2210/pdb3u6i/pdb
Related	3U6H 3U6J
Descriptor	Hepatocyte growth factor receptor, N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total)
Functional Keywords	kinase domain, phosphotransferase, cancer, hepatocyte growth factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains	1
Total formula weight	35758.27
Authors	Bellon, S.F.,Whittington, D.A.,Long, A.L. (deposition date: 2011-10-12, release date: 2012-02-22, Last modification date: 2023-09-13)
Primary citation	Norman, M.H.,Liu, L.,Lee, M.,Xi, N.,Fellows, I.,D'Angelo, N.D.,Dominguez, C.,Rex, K.,Bellon, S.F.,Kim, T.S.,Dussault, I. Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives. J.Med.Chem., 55:1858-1867, 2012 Cited by PubMed: 22320343 DOI: 10.1021/jm201330u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation