3TV6
Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor
Summary for 3TV6
Entry DOI | 10.2210/pdb3tv6/pdb |
Related | 3TV4 |
Descriptor | Serine/threonine-protein kinase B-raf, 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide (2 entities in total) |
Functional Keywords | b-raf, kinase, kinase inhibitor, transferase, c-raf, ras, mek, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71286.09 |
Authors | Voegtli, W.C.,Sturgis, H.L.,Wu, W.-I. (deposition date: 2011-09-19, release date: 2011-10-05, Last modification date: 2024-02-28) |
Primary citation | Wenglowsky, S.,Ren, L.,Ahrendt, K.A.,Laird, E.R.,Aliagas, I.,Alicke, B.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Feng, B.,Gloor, S.L.,Gould, S.E.,Gross, S.,Gunzner-Toste, J.,Hansen, J.D.,Hatzivassiliou, G.,Liu, B.,Malesky, K.,Mathieu, S.,Newhouse, B.,Raddatz, N.J.,Ran, Y.,Rana, S.,Randolph, N.,Risom, T.,Rudolph, J.,Savage, S.,Selby, L.T.,Shrag, M.,Song, K.,Sturgis, H.L.,Voegtli, W.C.,Wen, Z.,Willis, B.S.,Woessner, R.D.,Wu, W.I.,Young, W.B.,Grina, J. Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med Chem Lett, 2:342-347, 2011 Cited by PubMed: 24900315DOI: 10.1021/ml200025q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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