3TH8
Structure of E. coli undecaprenyl diphosphate synthase complexed with BPH-1063
Summary for 3TH8
Entry DOI | 10.2210/pdb3th8/pdb |
Descriptor | Undecaprenyl pyrophosphate synthase, (2Z)-4-({3-[3-(hexyloxy)phenyl]propyl}amino)-2-hydroxy-4-oxobut-2-enoic acid (3 entities in total) |
Functional Keywords | all helices, prenyl transferase, farneyl diphosphate binding, isopentenyl diphosphate binding, prenylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 57311.68 |
Authors | Cao, R.,Zhu, W.,Zhang, Y.,Oldfield, E. (deposition date: 2011-08-18, release date: 2012-07-04, Last modification date: 2023-09-13) |
Primary citation | Zhang, Y.,Lin, F.-Y.,Li, K.,Zhu, W.,Liu, Y.L.,Cao, R.,Pang, R.,Lee, E.,Axelson, J.,Hensler, M.,Wang, K.,Molohon, K.J.,Wang, Y.,Mitchell, D.A.,Nizet, V.,Oldfield, E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett, 3:402-406, 2012 Cited by PubMed: 22662288DOI: 10.1021/ml300038t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.114 Å) |
Structure validation
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