3SOS
Benzothiazinone inhibitor in complex with FXIa
Summary for 3SOS
| Entry DOI | 10.2210/pdb3sos/pdb |
| Related | 3SOR |
| Related PRD ID | PRD_001115 |
| Descriptor | Coagulation factor XI, CITRIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total) |
| Functional Keywords | hydrolase, serine protease, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P03951 |
| Total number of polymer chains | 1 |
| Total formula weight | 27732.81 |
| Authors | Fradera, X.,Kazemier, B.,Oubrie, A. (deposition date: 2011-06-30, release date: 2012-04-11, Last modification date: 2024-04-03) |
| Primary citation | Fradera, X.,Kazemier, B.,Carswell, E.,Cooke, A.,Oubrie, A.,Hamilton, W.,Dempster, M.,Krapp, S.,Nagel, S.,Jestel, A. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. Acta Crystallogr.,Sect.F, 68:404-408, 2012 Cited by PubMed: 22505407DOI: 10.1107/S1744309112009037 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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