3SI2
Structure of glycosylated murine glutaminyl cyclase in presence of the inhibitor PQ50 (PDBD150)
Summary for 3SI2
Entry DOI | 10.2210/pdb3si2/pdb |
Related | 3SI0 3SI1 |
Related PRD ID | PRD_900017 |
Descriptor | Glutaminyl-peptide cyclotransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total) |
Functional Keywords | alpha/beta hydrolase, alzheimer's disease, pyroglutamate, pglu, pe, pglu-amyloid, glycosylation, glycoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 1 |
Total formula weight | 38746.00 |
Authors | Parthier, C.,Carrillo, D.,Stubbs, M.T. (deposition date: 2011-06-17, release date: 2011-06-29, Last modification date: 2023-09-13) |
Primary citation | Ruiz-Carrillo, D.,Koch, B.,Parthier, C.,Wermann, M.,Dambe, T.,Buchholz, M.,Ludwig, H.H.,Heiser, U.,Rahfeld, J.U.,Stubbs, M.T.,Schilling, S.,Demuth, H.U. Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center. Biochemistry, 50:6280-6288, 2011 Cited by PubMed: 21671571DOI: 10.1021/bi200249h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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