3S4Q
P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor
Summary for 3S4Q
Entry DOI | 10.2210/pdb3s4q/pdb |
Descriptor | Mitogen-activated protein kinase 14, 3-[(6-benzoyl-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]-N-cyclopropyl-4-methylbenzamide (3 entities in total) |
Functional Keywords | p38 map kinase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42530.49 |
Authors | Sack, J.S. (deposition date: 2011-05-20, release date: 2012-02-01, Last modification date: 2024-02-28) |
Primary citation | Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Shen, D.R.,McIntyre, K.W.,Gillooly, K.M.,Shuster, D.J.,Doweyko, A.M.,Sack, J.S.,Kish, K.,Kiefer, S.E.,Newitt, J.A.,Zhang, H.,Marathe, P.H.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 21:4633-4637, 2011 Cited by PubMed: 21705217DOI: 10.1016/j.bmcl.2011.05.091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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