Summary for 3S2O
| Entry DOI | 10.2210/pdb3s2o/pdb |
| Related | 3MSJ 3MSK 3MSL 3MSM |
| Descriptor | Beta-secretase 1, (3S)-3-(2-amino-5-chloro-1H-benzimidazol-1-yl)-N-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]pentanamide, IODIDE ION, ... (4 entities in total) |
| Functional Keywords | protease, alzheimer's disease, aspartic protease, aspartyl protease, base, beta-secretase, glycoprotein, memapsin 2, amyloid precursor protein secretases, aspartic endopeptidases, fragment-based drug design, fluorescence polarisation, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
| Total number of polymer chains | 1 |
| Total formula weight | 46089.71 |
| Authors | Madden, J.,Godemann, R.,Smith, M.A.,Hallett, D.,Barker, J.,Kraemer, J. (deposition date: 2011-05-17, release date: 2011-06-01, Last modification date: 2023-09-13) |
| Primary citation | Madden, J.,Dod, J.R.,Godemann, R.,Kraemer, J.,Smith, M.,Biniszkiewicz, M.,Hallett, D.J.,Barker, J.,Dyekjaer, J.D.,Hesterkamp, T. Fragment-based discovery and optimization of BACE1 inhibitors. Bioorg.Med.Chem.Lett., 20:5329-5333, 2010 Cited by PubMed: 20656487DOI: 10.1016/j.bmcl.2010.06.089 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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