3RTH
Structure of Bace-1 (Beta-Secretase) in Complex with 6-(2-(3,3-Dimethylbut-1-ynyl)phenyl)quinolin-2-amine
Summary for 3RTH
Entry DOI | 10.2210/pdb3rth/pdb |
Related | 3RSV 3RSX 3RTM 3RTN |
Descriptor | Beta-secretase 1, IODIDE ION, 6-[2-(3,3-dimethylbut-1-yn-1-yl)phenyl]quinolin-2-amine, ... (4 entities in total) |
Functional Keywords | aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46630.46 |
Authors | Sickmier, E.A. (deposition date: 2011-05-03, release date: 2011-08-31, Last modification date: 2017-11-08) |
Primary citation | Cheng, Y.,Judd, T.C.,Bartberger, M.D.,Brown, J.,Chen, K.,Fremeau, R.T.,Hickman, D.,Hitchcock, S.A.,Jordan, B.,Li, V.,Lopez, P.,Louie, S.W.,Luo, Y.,Michelsen, K.,Nixey, T.,Powers, T.S.,Rattan, C.,Sickmier, E.A.,St Jean, D.J.,Wahl, R.C.,Wen, P.H.,Wood, S. From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1). J.Med.Chem., 54:5836-5857, 2011 Cited by PubMed: 21707077DOI: 10.1021/jm200544q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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