3RIN
p38 kinase crystal structure in complex with small molecule inhibitor
Summary for 3RIN
Entry DOI | 10.2210/pdb3rin/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-indol]-6'-yl)benzamide (3 entities in total) |
Functional Keywords | p38 map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41703.64 |
Authors | Segarra, V.,Eastwood, P.,Roca, R.,Fisher, M.,Lamers, M. (deposition date: 2011-04-14, release date: 2012-02-29, Last modification date: 2023-09-13) |
Primary citation | Eastwood, P.,Gonzalez, J.,Gomez, E.,Vidal, B.,Caturla, F.,Roca, R.,Balague, C.,Orellana, A.,Dominguez, M. Indolin-2-one p38(alpha) inhibitors I: design, profiling and crystallographic binding mode. Bioorg.Med.Chem.Lett., 21:4130-4133, 2011 Cited by PubMed: 21696951DOI: 10.1016/j.bmcl.2011.05.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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