3R30
MK2 kinase bound to Compound 2
Summary for 3R30
Entry DOI | 10.2210/pdb3r30/pdb |
Related | 3R1N 3R2B 3R2Y |
Descriptor | MAP kinase-activated protein kinase 2, 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1H-pyrazole-5-carboxylic acid (2 entities in total) |
Functional Keywords | kinase domain with bound inhibitor, kinase domain, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37252.04 |
Authors | Oubrie, A.,Fisher, M. (deposition date: 2011-03-15, release date: 2011-05-25, Last modification date: 2024-02-21) |
Primary citation | Barf, T.,Kaptein, A.,Wilde, S.,Heijden, R.,Someren, R.,Demont, D.,Schultz-Fademrecht, C.,Versteegh, J.,Zeeland, M.,Seegers, N.,Kazemier, B.,Kar, B.,Hoek, M.,Roos, J.,Klop, H.,Smeets, R.,Hofstra, C.,Hornberg, J.,Oubrie, A. Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg.Med.Chem.Lett., 21:3818-3822, 2011 Cited by PubMed: 21565500DOI: 10.1016/j.bmcl.2011.04.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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