3R0W

Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors.

Summary for 3R0W

• Entry DOI: 10.2210/pdb3r0w/pdb
• Related: 3R0Y
• Related PRD ID: PRD_001110
• Descriptor: Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2R)-1-{[(2S,3S)-5-{[(2R)-1-{[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino}-3-chloro-1-oxopropan-2-yl]amino}-3-hydroxy-5-oxo-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22170.43

Authors

Yedidi, R.S.,Gupta, D.,Liu, Z.,Brunzelle, J.,Kovari, I.A.,Woster, P.M.,Kovari, L.C. (deposition date: 2011-03-09, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Yedidi, R.S.,Liu, Z.,Wang, Y.,Brunzelle, J.S.,Kovari, I.A.,Woster, P.M.,Kovari, L.C.,Gupta, D.; Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.; Biochem.Biophys.Res.Commun., 421:413-417, 2012; PubMed: 22469467; DOI: 10.1016/j.bbrc.2012.03.096

Experimental method

X-RAY DIFFRACTION (1.7 Å)