3QVI
Crystal structure of KNI-10395 bound histo-aspartic protease (HAP) from Plasmodium falciparum
Summary for 3QVI
Entry DOI | 10.2210/pdb3qvi/pdb |
Related | 3QVC |
Related PRD ID | PRD_001055 |
Descriptor | Histo-aspartic protease, (4R)-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-3-[(2S,3S)-2-hydroxy-3-{[S-methyl-N-(phenylacetyl)-L-cysteinyl]amino}-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, 1,2-ETHANEDIOL, ... (8 entities in total) |
Functional Keywords | histo-aspartic protease, hap, plasmepsin, aspartic protease, malaria, kni, kni-10395, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum |
Total number of polymer chains | 4 |
Total formula weight | 210916.57 |
Authors | Bhaumik, P.,Gustchina, A.,Wlodawer, A. (deposition date: 2011-02-25, release date: 2011-10-12, Last modification date: 2013-09-04) |
Primary citation | Bhaumik, P.,Xiao, H.,Hidaka, K.,Gustchina, A.,Kiso, Y.,Yada, R.Y.,Wlodawer, A. Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum. Biochemistry, 50:8862-8879, 2011 Cited by PubMed: 21928835DOI: 10.1021/bi201118z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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