3QQD

Human SOD1 H80R variant, P212121 crystal form

Replaces:  3H2R

Summary for 3QQD

• Entry DOI: 10.2210/pdb3qqd/pdb
• Related: 3H2P 3H2Q
• Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: oxidoreductase, human cu, zn superoxide dismutase, antioxidant, metal-binding, amyotrophic lateral sclerosis, disease mutation, disulfide bond
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P00441 P00441
• Total number of polymer chains: 2
• Total formula weight: 32132.24

Authors

Seetharaman, S.V.,Winkler, D.D.,Taylor, A.B.,Cao, X.,Whitson, L.J.,Doucette, P.A.,Valentine, J.S.,Schirf, V.,Demeler, B.,Carroll, M.C.,Culotta, V.C.,Hart, P.J. (deposition date: 2011-02-15, release date: 2011-03-09, Last modification date: 2023-12-06)

• Primary citation: Seetharaman, S.V.,Winkler, D.D.,Taylor, A.B.,Cao, X.,Whitson, L.J.,Doucette, P.A.,Valentine, J.S.,Schirf, V.,Demeler, B.,Carroll, M.C.,Culotta, V.C.,Hart, P.J.; Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.; Biochemistry, 49:5714-5725, 2010; PubMed: 20515040; DOI: 10.1021/bi100314n

Experimental method

X-RAY DIFFRACTION (1.653 Å)