3Q06
An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
Summary for 3Q06
Entry DOI | 10.2210/pdb3q06/pdb |
Related | 3Q01 3Q05 |
Descriptor | Cellular tumor antigen p53, DNA (26-MER), ZINC ION, ... (4 entities in total) |
Functional Keywords | beta sandwich, multidomain, oligomerization, tp53, p53, tumor suppressor, dimer, dna binding, cell cycle-dna complex, cell cycle/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 6 |
Total formula weight | 121841.70 |
Authors | Petty, T.J.,Halazonetis, T.D. (deposition date: 2010-12-15, release date: 2011-05-11, Last modification date: 2023-09-13) |
Primary citation | Petty, T.J.,Emamzadah, S.,Costantino, L.,Petkova, I.,Stavridi, E.S.,Saven, J.G.,Vauthey, E.,Halazonetis, T.D. An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. Embo J., 30:2167-2176, 2011 Cited by PubMed: 21522129DOI: 10.1038/emboj.2011.127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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