3PRF
Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor
Summary for 3PRF
Entry DOI | 10.2210/pdb3prf/pdb |
Related | 3PPJ 3PPK 3PRI |
Descriptor | Serine/threonine-protein kinase B-raf, 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol (2 entities in total) |
Functional Keywords | protein kinase, atp-competitive inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71112.76 |
Authors | Voegtli, W.C.,Vigers, G.P.A.,Morales, T.,Brandhuber, B.J. (deposition date: 2010-11-29, release date: 2011-02-02, Last modification date: 2024-02-21) |
Primary citation | Ren, L.,Wenglowsky, S.,Miknis, G.,Rast, B.,Buckmelter, A.J.,Ely, R.J.,Schlachter, S.,Laird, E.R.,Randolph, N.,Callejo, M.,Martinson, M.,Galbraith, S.,Brandhuber, B.J.,Vigers, G.,Morales, T.,Voegtli, W.C.,Lyssikatos, J. Non-oxime inhibitors of B-Raf(V600E) kinase. Bioorg.Med.Chem.Lett., 21:1243-1247, 2011 Cited by PubMed: 21251822DOI: 10.1016/j.bmcl.2010.12.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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