3PIX
Crystal structure of BTK kinase domain complexed with 2-Isopropyl-7-(4-methyl-piperazin-1-yl)-4-(5-methyl-2H-pyrazol-3-ylamino)-2H-phthalazin-1-one
Summary for 3PIX
Entry DOI | 10.2210/pdb3pix/pdb |
Related | 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 |
Descriptor | Tyrosine-protein kinase BTK, 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2H)-one (3 entities in total) |
Functional Keywords | helix c-out, dfg-in, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32209.00 |
Authors | Kuglstatter, A.,Wong, A. (deposition date: 2010-11-08, release date: 2011-01-12, Last modification date: 2023-09-06) |
Primary citation | Kuglstatter, A.,Wong, A.,Tsing, S.,Lee, S.W.,Lou, Y.,Villasenor, A.G.,Bradshaw, J.M.,Shaw, D.,Barnett, J.W.,Browner, M.F. Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20:428-436, 2011 Cited by PubMed: 21280133DOI: 10.1002/pro.575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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