3PG3
Human p38 MAP Kinase in Complex with RL182
Summary for 3PG3
Entry DOI | 10.2210/pdb3pg3/pdb |
Related | 3IW8 |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, ... (4 entities in total) |
Functional Keywords | dfg-out, sar, kinase domain, thiazole-urea, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42017.96 |
Authors | Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2010-10-29, release date: 2011-11-02, Last modification date: 2023-09-06) |
Primary citation | Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D. Structure-based design and synthesis of cell active N-pyrazole, N-thiazole urea inhibitors of the MAP kinase p38alpha To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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