3PG3

Human p38 MAP Kinase in Complex with RL182

Summary for 3PG3

• Entry DOI: 10.2210/pdb3pg3/pdb
• Related: 3IW8
• Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-{4-[2-(pyridin-3-ylmethoxy)ethyl]-1,3-thiazol-2-yl}urea, ... (4 entities in total)
• Functional Keywords: dfg-out, sar, kinase domain, thiazole-urea, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42017.96

Authors

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2010-10-29, release date: 2011-11-02, Last modification date: 2023-09-06)

• Primary citation: Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D.; Structure-based design and synthesis of cell active N-pyrazole, N-thiazole urea inhibitors of the MAP kinase p38alpha; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)