3P9W

Crystal structure of an engineered human autonomous VH Domain in complex with VEGF

Summary for 3P9W

• Entry DOI: 10.2210/pdb3p9w/pdb
• Related: 3B9V
• Descriptor: Vascular endothelial growth factor A, human VEGF (3 entities in total)
• Functional Keywords: vh, cystine knot cytokine, vegf-r, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P15692
• Total number of polymer chains: 8
• Total formula weight: 103516.51

Authors

Ma, X.,Wiesmann, C. (deposition date: 2010-10-18, release date: 2012-04-18, Last modification date: 2013-06-19)

• Primary citation: Ma, X.,Barthelemy, P.A.,Rouge, L.,Wiesmann, C.,Sidhu, S.S.; Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.; J.Mol.Biol., 425:2247-2259, 2013; PubMed: 23507309; DOI: 10.1016/j.jmb.2013.03.020

Experimental method

X-RAY DIFFRACTION (2.41 Å)