3P55
Human carbonic anhydrase II in complex with p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide
Summary for 3P55
| Entry DOI | 10.2210/pdb3p55/pdb |
| Descriptor | Carbonic anhydrase 2, p-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)benzenesulfonamide, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | carbonic anhydrase alpha, lyase, cytosolic |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29938.85 |
| Authors | Salmon, A.J. (deposition date: 2010-10-07, release date: 2011-10-12, Last modification date: 2023-11-01) |
| Primary citation | Salmon, A.J.,Williams, M.L.,Hofmann, A.,Poulsen, S.A. Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors. Chem.Commun.(Camb.), 48:2328-2330, 2012 Cited by PubMed Abstract: We have determined the protein X-ray crystal structures of four organometallic inhibitors in complex with their target enzyme carbonic anhydrase II. The barrel-shaped hydrophobic ferrocene and ruthenocene moieties have provided a structure-based avenue to better occupy the hydrophobic binding patch within the enzyme active site. PubMed: 22258283DOI: 10.1039/c2cc15625c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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