3OZR
Rat catechol O-methyltransferase in complex with a catechol-type, bisubstrate inhibitor, no substituent in the adenine site - humanized form
Summary for 3OZR
Entry DOI | 10.2210/pdb3ozr/pdb |
Related | 3NW9 3NWB 3NWE 3OZS 3OZT |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, magnesium, metal-binding, s-adenosyl-l-methionine, signal-anchor, transferase, transmembrane methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25094.38 |
Authors | Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (deposition date: 2010-09-27, release date: 2011-03-16, Last modification date: 2024-04-03) |
Primary citation | Ellermann, M.,Paulini, R.,Jakob-Roetne, R.,Lerner, C.,Borroni, E.,Roth, D.,Ehler, A.,Schweizer, W.B.,Schlatter, D.,Rudolph, M.G.,Diederich, F. Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors Chemistry, 17:6369-6381, 2011 Cited by PubMed: 21538606DOI: 10.1002/chem.201003648 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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