3ODU

The 2.5 A structure of the CXCR4 chemokine receptor in complex with small molecule antagonist IT1t

Summary for 3ODU

• Entry DOI: 10.2210/pdb3odu/pdb
• Related: 3OE0 3OE6 3OE8 3OE9
• Descriptor: C-X-C chemokine receptor type 4, Lysozyme Chimera, (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (5 entities in total)
• Functional Keywords: structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemokine, cxcl12, sdf1, isothiourea, chimera, t4l fusion, membrane protein, transmembrane, singnaling protein, psi-biology, gpcr network, signaling protein
• Biological source: Homo Sapiens; More
• Cellular location: Cell membrane; Multi-pass membrane protein: P61073
• Total number of polymer chains: 2
• Total formula weight: 118216.37

Authors

Wu, B.,Mol, C.D.,Han, G.W.,Katritch, V.,Chien, E.Y.T.,Liu, W.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (deposition date: 2010-08-11, release date: 2010-10-27, Last modification date: 2021-10-06)

• Primary citation: Wu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C.; Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.; Science, 330:1066-1071, 2010; PubMed: 20929726; DOI: 10.1126/science.1194396

Experimental method

X-RAY DIFFRACTION (2.5 Å)