3OAF

Structural and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Thier Active Site Mutants

Summary for 3OAF

• Entry DOI: 10.2210/pdb3oaf/pdb
• Related: 3l3w
• Descriptor: Dihydrofolate reductase, 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hdhfr inhibitor complexes, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 1
• Total formula weight: 22157.05

Authors

Cody, V. (deposition date: 2010-08-05, release date: 2011-08-03, Last modification date: 2023-09-06)

• Primary citation: Cody, V.,Pace, J.,Queener, S.F.,Adair, O.O.,Gangjee, A.; Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.; Antimicrob.Agents Chemother., 57:2669-2677, 2013; PubMed: 23545530; DOI: 10.1128/AAC.00172-13

Experimental method

X-RAY DIFFRACTION (1.7 Å)