3NYA

Crystal structure of the human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol

Summary for 3NYA

Entry DOI	10.2210/pdb3nya/pdb
Related	2RH1 3D4S 3NY8 3NY9
Descriptor	Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, ... (4 entities in total)
Functional Keywords	g protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenaline, alprenolol, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-biology, gpcr network, gpcr
Biological source	Homo sapiens More
Cellular location	Cell membrane ; Multi- pass membrane protein : P07550
Total number of polymer chains	1
Total formula weight	56980.58
Authors	Brown, M.A.,Wacker, D.,Fenalti, G.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (deposition date: 2010-07-14, release date: 2010-08-11, Last modification date: 2023-09-06)
Primary citation	Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C. Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography J.Am.Chem.Soc., 132:11443-11445, 2010 Cited by PubMed: 20669948 DOI: 10.1021/ja105108q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.16 Å)

Structure validation