3NXT

Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase

Summary for 3NXT

Entry DOI	10.2210/pdb3nxt/pdb
Related	3NXO 3NXR 3NXV 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZB 3NZC 3NZD 3d7x 3d7y 3gyf
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(E)-2-cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total)
Functional Keywords	chiral selectivity e-z-isomers, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	22801.56
Authors	Cody, V. (deposition date: 2010-07-14, release date: 2010-12-01, Last modification date: 2024-04-03)
Primary citation	Cody, V.,Piraino, J.,Pace, J.,Li, W.,Gangjee, A. Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 66:1271-1277, 2010 Cited by PubMed: 21123866 DOI: 10.1107/S0907444910035808 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation