3NS7
Succinic Acid Amides as P2-P3 Replacements for Inhibitors of Interleukin-1beta Converting Enzyme (ICE or Caspase 1)
Summary for 3NS7
Entry DOI | 10.2210/pdb3ns7/pdb |
Related PRD ID | PRD_001011 |
Descriptor | Caspase-1, (3S)-4-hydroxy-3-{[(2S)-4-{[2-(2-methyl-1H-benzimidazol-1-yl)ethyl]amino}-2-(1-methylethyl)-4-oxobutanoyl]amino}butanoic acid, ... (4 entities in total) |
Functional Keywords | cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29466 P29466 |
Total number of polymer chains | 2 |
Total formula weight | 28975.34 |
Authors | Galatsis, P. (deposition date: 2010-07-01, release date: 2011-08-17, Last modification date: 2023-12-27) |
Primary citation | Galatsis, P.,Caprathe, B.,Gilmore, J.,Thomas, A.,Linn, K.,Sheehan, S.,Harter, W.,Kostlan, C.,Lunney, E.,Stankovic, C.,Rubin, J.,Brady, K.,Allen, H.,Talanian, R. Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg.Med.Chem.Lett., 20:5184-5190, 2010 Cited by PubMed: 20656488DOI: 10.1016/j.bmcl.2010.07.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report