3NNY
Structure of rat neuronal nitric oxide synthase heme domain complexed with 6-(((3R,4R)-4-(2-(3-Fluorophenethylamino)ethoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine
Summary for 3NNY
Entry DOI | 10.2210/pdb3nny/pdb |
Related | 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNZ |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase, heme enzyme, inhibitor, oxidoreductase |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Total number of polymer chains | 2 |
Total formula weight | 100240.93 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2010-06-24, release date: 2010-10-06, Last modification date: 2023-09-06) |
Primary citation | Xue, F.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase. Bioorg.Med.Chem.Lett., 20:6258-6261, 2010 Cited by PubMed: 20833542DOI: 10.1016/j.bmcl.2010.08.096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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