3NF8
Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
Summary for 3NF8
Entry DOI | 10.2210/pdb3nf8/pdb |
Related | 1bhl 1bi4 1biu 1ex4 1k6y 3NF6 3NF7 3NF9 3NFA |
Descriptor | Integrase, SULFATE ION, 6-[(5-chloro-2-oxo-2,3-dihydro-1H-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid, ... (5 entities in total) |
Functional Keywords | integrase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 42944.39 |
Authors | Peat, T.S.,Newman, J.,Deadman, J.J.,Rhodes, D. (deposition date: 2010-06-09, release date: 2011-04-27, Last modification date: 2024-03-20) |
Primary citation | Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.,Jeevarajah, D.,Le, G.,Jones, E.D.,Smith, J.A.,Coates, J.A.,Winfield, L.J.,Thienthong, N.,Newman, J.,Lucent, D.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21:155-168, 2011 Cited by PubMed: 21602613DOI: 10.3851/IMP1716 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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