3NCG

Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with bumped kinase inhibitor NM-PP1

Summary for 3NCG

Entry DOI	10.2210/pdb3ncg/pdb
Related	3I79 3I7b 3I7c 3IGO 3MWU 3N51
Descriptor	Calmodulin-domain protein kinase 1, CALCIUM ION, 1-(1-methylethyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... (4 entities in total)
Functional Keywords	serine/threonine protein kinase, transferase, calcium-binding, atp-binding, calmodulin, bumped kinase inhibitor, transferase-transferase inhibitor complex, structural genomics, medical structural genomics of pathogenic protozoa, msgpp, transferase/transferase inhibitor
Biological source	Cryptosporidium parvum
Total number of polymer chains	1
Total formula weight	56590.41
Authors	Larson, E.T.,Merritt, E.A.,Medical Structural Genomics of Pathogenic Protozoa (MSGPP) (deposition date: 2010-06-04, release date: 2010-07-21, Last modification date: 2023-09-06)
Primary citation	Murphy, R.C.,Ojo, K.K.,Larson, E.T.,Castellanos-Gonzalez, A.,Perera, B.G.,Keyloun, K.R.,Kim, J.E.,Bhandari, J.G.,Muller, N.R.,Verlinde, C.L.,White, A.C.,Merritt, E.A.,Van Voorhis, W.C.,Maly, D.J. Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett, 1:331-335, 2010 Cited by PubMed: 21116453 DOI: 10.1021/ml100096t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation