3MW1

p38 kinase Crystal structure in complex with small molecule inhibitor

Summary for 3MW1

Entry DOI	10.2210/pdb3mw1/pdb
Related	3HRB
Descriptor	Mitogen-activated protein kinase 14, 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-2-piperidin-4-yl-1,7-naphthyridine 7-oxide (3 entities in total)
Functional Keywords	p38 map kinase, transferase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	41698.34
Authors	Segarra, V.,Caturla, F.,Lumeras, W.,Roca, R.,Fisher, M.,Lamers, M. (deposition date: 2010-05-05, release date: 2011-04-27, Last modification date: 2023-11-01)
Primary citation	Lumeras, W.,Vidal, L.,Vidal, B.,Balague, C.,Orellana, A.,Maldonado, M.,Dominguez, M.,Segarra, V.,Caturla, F. 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase J.Med.Chem., 54:7899-7910, 2011 Cited by PubMed: 21999461 DOI: 10.1021/jm200975u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation