3MW1
p38 kinase Crystal structure in complex with small molecule inhibitor
Summary for 3MW1
Entry DOI | 10.2210/pdb3mw1/pdb |
Related | 3HRB |
Descriptor | Mitogen-activated protein kinase 14, 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-2-piperidin-4-yl-1,7-naphthyridine 7-oxide (3 entities in total) |
Functional Keywords | p38 map kinase, transferase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41698.34 |
Authors | Segarra, V.,Caturla, F.,Lumeras, W.,Roca, R.,Fisher, M.,Lamers, M. (deposition date: 2010-05-05, release date: 2011-04-27, Last modification date: 2023-11-01) |
Primary citation | Lumeras, W.,Vidal, L.,Vidal, B.,Balague, C.,Orellana, A.,Maldonado, M.,Dominguez, M.,Segarra, V.,Caturla, F. 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase J.Med.Chem., 54:7899-7910, 2011 Cited by PubMed: 21999461DOI: 10.1021/jm200975u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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