3MKE
SHV-1 beta-lactamase complex with LP06
Summary for 3MKE
Entry DOI | 10.2210/pdb3mke/pdb |
Related | 3MKF |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... (5 entities in total) |
Functional Keywords | beta-lactamase, boronic acid transition state inhibitor, drug design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30666.61 |
Authors | van den Akker, F.,Ke, W. (deposition date: 2010-04-14, release date: 2010-11-24, Last modification date: 2023-09-06) |
Primary citation | Ke, W.,Sampson, J.M.,Ori, C.,Prati, F.,Drawz, S.M.,Bethel, C.R.,Bonomo, R.A.,van den Akker, F. Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors. Antimicrob.Agents Chemother., 55:174-183, 2011 Cited by PubMed: 21041505DOI: 10.1128/AAC.00930-10 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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