3MKE

SHV-1 beta-lactamase complex with LP06

Summary for 3MKE

• Entry DOI: 10.2210/pdb3mke/pdb
• Related: 3MKF
• Descriptor: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... (5 entities in total)
• Functional Keywords: beta-lactamase, boronic acid transition state inhibitor, drug design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30666.61

Authors

van den Akker, F.,Ke, W. (deposition date: 2010-04-14, release date: 2010-11-24, Last modification date: 2023-09-06)

• Primary citation: Ke, W.,Sampson, J.M.,Ori, C.,Prati, F.,Drawz, S.M.,Bethel, C.R.,Bonomo, R.A.,van den Akker, F.; Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.; Antimicrob.Agents Chemother., 55:174-183, 2011; PubMed: 21041505; DOI: 10.1128/AAC.00930-10

Experimental method

X-RAY DIFFRACTION (1.75 Å)