3MH3
Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
Replaces: 2PTJSummary for 3MH3
Entry DOI | 10.2210/pdb3mh3/pdb |
Related | 3MGY 3MH0 3MH1 3MH2 |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside (3 entities in total) |
Functional Keywords | signaling protein, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41645.58 |
Authors | Namboodiri, H.V.,Karpusas, M.,Bukhtiyarova, M.,Springman, E.B. (deposition date: 2010-04-07, release date: 2010-04-21, Last modification date: 2023-09-06) |
Primary citation | Bukhtiyarova, M.,Karpusas, M.,Northrop, K.,Namboodiri, H.V.,Springman, E.B. Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state. Biochemistry, 46:5687-5696, 2007 Cited by PubMed: 17441692DOI: 10.1021/bi0622221 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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