3LJ3
PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor
Summary for 3LJ3
Entry DOI | 10.2210/pdb3lj3/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, (2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one, ... (4 entities in total) |
Functional Keywords | atp-binding, kinase, nucleotide-binding, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P48736 |
Total number of polymer chains | 1 |
Total formula weight | 111354.72 |
Authors | Bard, J.,Svenson, K. (deposition date: 2010-01-25, release date: 2010-04-14, Last modification date: 2023-09-06) |
Primary citation | Tsou, H.R.,MacEwan, G.,Birnberg, G.,Grosu, G.,Bursavich, M.G.,Bard, J.,Brooijmans, N.,Toral-Barza, L.,Hollander, I.,Mansour, T.S.,Ayral-Kaloustian, S.,Yu, K. Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg.Med.Chem.Lett., 20:2321-2325, 2010 Cited by PubMed: 20188552DOI: 10.1016/j.bmcl.2010.01.135 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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