3LFQ

Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor

Summary for 3LFQ

Entry DOI	10.2210/pdb3lfq/pdb
Related	3FLN 3FLS
Descriptor	Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide (3 entities in total)
Functional Keywords	protein kinase fold, acetylation, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34291.81
Authors	Dreyer, M.K.,Wendt, K.U.,Schimanski-Breves, S.,Loenze, P. (deposition date: 2010-01-18, release date: 2010-03-02, Last modification date: 2024-02-21)
Primary citation	Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T. Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20:1985-1989, 2010 Cited by PubMed: 20167481 DOI: 10.1016/j.bmcl.2010.01.114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.03 Å)

Structure validation