3LFA

Human p38 MAP Kinase in Complex with Dasatinib

Summary for 3LFA

• Entry DOI: 10.2210/pdb3lfa/pdb
• Related: 3LFB 3LFC 3LFD 3LFE 3LFF
• Descriptor: Mitogen-activated protein kinase 14, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: thiazole-urea, dfg-out, sar, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42049.43

Authors

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2010-01-16, release date: 2011-04-20, Last modification date: 2023-09-06)

• Primary citation: Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D.; Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)