3LFA
Human p38 MAP Kinase in Complex with Dasatinib
Summary for 3LFA
Entry DOI | 10.2210/pdb3lfa/pdb |
Related | 3LFB 3LFC 3LFD 3LFE 3LFF |
Descriptor | Mitogen-activated protein kinase 14, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | thiazole-urea, dfg-out, sar, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42049.43 |
Authors | Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (deposition date: 2010-01-16, release date: 2011-04-20, Last modification date: 2023-09-06) |
Primary citation | Getlik, M.,Gruetter, C.,Simard, J.R.,Van Otterlo, W.,Robubi, A.,Aust, B.,Rauh, D. Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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