3L0J
Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand
Summary for 3L0J
Entry DOI | 10.2210/pdb3l0j/pdb |
Descriptor | Nuclear receptor ROR-gamma, Nuclear receptor coactivator 2, (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, ... (4 entities in total) |
Functional Keywords | ror gamma, nuclear receptors, alternative splicing, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, acetylation, activator, phosphoprotein, polymorphism |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Probable): P51449 Nucleus: Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 29935.94 |
Authors | Martynowski, D.,Li, Y. (deposition date: 2009-12-10, release date: 2010-03-16, Last modification date: 2024-02-21) |
Primary citation | Jin, L.,Martynowski, D.,Zheng, S.,Wada, T.,Xie, W.,Li, Y. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol.Endocrinol., 24:923-929, 2010 Cited by PubMed: 20203100DOI: 10.1210/me.2009-0507 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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