3KVW
Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand
Summary for 3KVW
Entry DOI | 10.2210/pdb3kvw/pdb |
Related | 3K2L |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 2, (2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | dyrk2, dual-specificity tyrosine, ki-(y)-phosphorylation regulated kinase 2, psk-h2, kinase, structural genomics consortium, sgc, apoptosis, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q92630 |
Total number of polymer chains | 1 |
Total formula weight | 50142.90 |
Authors | Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-11-30, release date: 2010-01-05, Last modification date: 2023-11-22) |
Primary citation | Filippakopoulos, P.,Myrianthopoulos, V.,Kritsanida, M.,Magiatis, P.,Skaltsounis, A.L.,Soundararajan, M.,Krojer, T.,Gileadi, O.,Hapka, E.,Fedorov, O.,Berridge, G.,Wang, J.,Shrestha, L.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Mikros, E.,Knapp, S. Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
Download full validation report