3KQ7

Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide

Summary for 3KQ7

• Entry DOI: 10.2210/pdb3kq7/pdb
• Descriptor: Mitogen-activated protein kinase p38 alpha, N-(2-methyl-5-{[(2-morpholin-4-ylpyridin-4-yl)carbonyl]amino}phenyl)-6-({2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}amino)py ridine-3-carboxamide, ACETATE ION, ... (4 entities in total)
• Functional Keywords: p38alpha kinase, alternative splicing, atp binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 44353.42

Authors

Cheng, R.K.Y.,Barker, J.,Whittaker, M. (deposition date: 2009-11-17, release date: 2009-12-01, Last modification date: 2023-09-06)

• Primary citation: Cheng, R.K.Y.,Barker, J.,Whittaker, M.; Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.8 Å)