3KK6
Crystal Structure of Cyclooxygenase-1 in complex with celecoxib
Summary for 3KK6
Entry DOI | 10.2210/pdb3kk6/pdb |
Descriptor | Prostaglandin G/H synthase 1, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, celecoxib, merohedral twinned, dioxygenase, disulfide bond, egf-like domain, endoplasmic reticulum, fatty acid biosynthesis, glycoprotein, iron, lipid synthesis, membrane, metal-binding, microsome, oxidoreductase, prostaglandin biosynthesis, transmembrane |
Biological source | Ovis aries (domestic sheep,lambs,wild sheep) |
Total number of polymer chains | 2 |
Total formula weight | 133735.28 |
Authors | Sidhu, R.S. (deposition date: 2009-11-04, release date: 2009-12-15, Last modification date: 2023-09-06) |
Primary citation | Rimon, G.,Sidhu, R.S.,Lauver, D.A.,Lee, J.Y.,Sharma, N.P.,Yuan, C.,Frieler, R.A.,Trievel, R.C.,Lucchesi, B.R.,Smith, W.L. Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. Proc.Natl.Acad.Sci.USA, 107:28-33, 2010 Cited by PubMed: 19955429DOI: 10.1073/pnas.0909765106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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