3K99

HSP90 N-terminal domain in complex with 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol

Summary for 3K99

Entry DOI	10.2210/pdb3k99/pdb
Related	3K97 3K98
Descriptor	Heat shock protein HSP 90-alpha, 4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)benzene-1,3-diol (3 entities in total)
Functional Keywords	hsp90, n-terminal domain, atp binding domain, inhibition, acetylation, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	4
Total formula weight	106668.00
Authors	Gajiwala, K.S.,Davies II, J.F. (deposition date: 2009-10-15, release date: 2010-02-09, Last modification date: 2024-02-21)
Primary citation	Kung, P.P.,Huang, B.,Zhang, G.,Zhou, J.Z.,Wang, J.,Digits, J.A.,Skaptason, J.,Yamazaki, S.,Neul, D.,Zientek, M.,Elleraas, J.,Mehta, P.,Yin, M.J.,Hickey, M.J.,Gajiwala, K.S.,Rodgers, C.,Davies, J.F.,Gehring, M.R. Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone. J.Med.Chem., 53:499-503, 2010 Cited by PubMed: 19908836 DOI: 10.1021/jm901209q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation