3K5V

Structure of Abl kinase in complex with imatinib and GNF-2

Summary for 3K5V

• Entry DOI: 10.2210/pdb3k5v/pdb
• Related: 1OPJ
• Descriptor: Tyrosine-protein kinase ABL1, 3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)benzamide, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (5 entities in total)
• Functional Keywords: kinase, atp-binding, nucleotide-binding, oncogene, sh2 domain, transferase, tyrosine-protein kinase
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm, cytoskeleton: P00520
• Total number of polymer chains: 2
• Total formula weight: 69258.34

Authors

Cowan-Jacob, S.W.,Fendrich, G.,Rummel, G.,Strauss, A. (deposition date: 2009-10-08, release date: 2010-01-19, Last modification date: 2023-09-06)

• Primary citation: Zhang, J.,Adrian, F.J.,Jahnke, W.,Cowan-Jacob, S.W.,Li, A.G.,Iacob, R.E.,Sim, T.,Powers, J.,Dierks, C.,Sun, F.,Guo, G.R.,Ding, Q.,Okram, B.,Choi, Y.,Wojciechowski, A.,Deng, X.,Liu, G.,Fendrich, G.,Strauss, A.,Vajpai, N.,Grzesiek, S.,Tuntland, T.,Liu, Y.,Bursulaya, B.,Azam, M.,Manley, P.W.,Engen, J.R.,Daley, G.Q.,Warmuth, M.,Gray, N.S.; Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.; Nature, 463:501-506, 2010; PubMed: 20072125; DOI: 10.1038/nature08675

Experimental method

X-RAY DIFFRACTION (1.74 Å)