3JPP

Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-MonoMethyl Methylene triphosphate

Summary for 3JPP

• Entry DOI: 10.2210/pdb3jpp/pdb
• Related: 3JPN 3JPO 3JPQ 3JPR 3JPS 3JPT
• Descriptor: DNA polymerase beta, 5'-D(P*GP*TP*CP*GP*G)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... (9 entities in total)
• Functional Keywords: dna polymerase, transferase, stereoselectivity, halogenated analogs, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 48429.16

Authors

Batra, V.K.,Upton, J.,Kashmerov, B.,Beard, W.A.,Wilson, S.H.,Goodman, M.F.,McKenna, C.E. (deposition date: 2009-09-04, release date: 2010-06-02, Last modification date: 2023-09-06)

• Primary citation: Batra, V.K.,Pedersen, L.C.,Beard, W.A.,Wilson, S.H.,Kashemirov, B.A.,Upton, T.G.,Goodman, M.F.,McKenna, C.E.; Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues.; J.Am.Chem.Soc., 132:7617-7625, 2010; PubMed: 20465217; DOI: 10.1021/ja909370k

Experimental method

X-RAY DIFFRACTION (2.1 Å)