3IO7
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Summary for 3IO7
Entry DOI | 10.2210/pdb3io7/pdb |
Descriptor | Tyrosine-protein kinase JAK2, (3S)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-N,N-diethylpiperidine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, inhibitor, jak2, janus kinase, atp-binding, chromosomal rearrangement, disease mutation, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 1 |
Total formula weight | 37177.28 |
Authors | Zuccola, H.J.,Ledeboer, M.W.,Pierce, A.C. (deposition date: 2009-08-13, release date: 2009-11-10, Last modification date: 2024-03-13) |
Primary citation | Ledeboer, M.W.,Pierce, A.C.,Duffy, J.P.,Gao, H.,Messersmith, D.,Salituro, F.G.,Nanthakumar, S.,Come, J.,Zuccola, H.J.,Swenson, L.,Shlyakter, D.,Mahajan, S.,Hoock, T.,Fan, B.,Tsai, W.J.,Kolaczkowski, E.,Carrier, S.,Hogan, J.K.,Zessis, R.,Pazhanisamy, S.,Bennani, Y.L. 2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2. Bioorg.Med.Chem.Lett., 19:6529-6533, 2009 Cited by PubMed: 19857967DOI: 10.1016/j.bmcl.2009.10.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report