3INX

HSP90 N-TERMINAL DOMAIN with pochoxime B

Summary for 3INX

• Entry DOI: 10.2210/pdb3inx/pdb
• Related: 3INW
• Descriptor: Heat shock protein HSP 90-alpha, DIMETHYL SULFOXIDE, (5E,9E,11E)-14,16-dihydroxy-3,4,7,8-tetrahydro-1H-2-benzoxacyclotetradecine-1,11(12H)-dione 11-[O-(2-oxo-2-piperidin-1-ylethyl)oxime], ... (4 entities in total)
• Functional Keywords: alpha beta, 2-layer sandwich, atp-binding, chaperone, nucleotide-binding, phosphoprotein, stress response, sp, ral, radicicol, pochonin, pochoxime
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 26271.65

Authors

Korndoerfer, I.P. (deposition date: 2009-08-13, release date: 2010-08-18, Last modification date: 2023-09-06)

• Primary citation: Barluenga, S.,Fontaine, J.G.,Wang, C.,Aouadi, K.,Chen, R.,Beebe, K.,Neckers, L.,Winssinger, N.; Inhibition of HSP90 with pochoximes: SAR and structure-based insights.; Chembiochem, 10:2753-2759, 2009; PubMed: 19856365; DOI: 10.1002/cbic.200900494

Experimental method

X-RAY DIFFRACTION (1.75 Å)