3HVI
Rat catechol O-methyltransferase in complex with a catechol-type, N6-ethyladenine-containing bisubstrate inhibitor
Summary for 3HVI
Entry DOI | 10.2210/pdb3hvi/pdb |
Related | 3HVH 3HVJ 3HVK |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, SODIUM ION, ... (7 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, s-adenosyl-l-methionine, signal-anchor, transferase, transmembrane |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25557.92 |
Authors | Ehler, A.,Schlatter, D.,Stihle, M.,Benz, J.,Rudolph, M.G. (deposition date: 2009-06-16, release date: 2009-10-13, Last modification date: 2024-03-20) |
Primary citation | Ellermann, M.,Jakob-Roetne, R.,Lerner, C.,Borroni, E.,Schlatter, D.,Roth, D.,Ehler, A.,Rudolph, M.G.,Diederich, F. Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor. Angew.Chem.Int.Ed.Engl., 48:9092-9096, 2009 Cited by PubMed: 19882607DOI: 10.1002/anie.200904410 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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