3HCC

Crystal Structure of hPNMT in Complex With anti-9-amino-5-(trifluromethyl) benzonorbornene and AdoHcy

Summary for 3HCC

Entry DOI	10.2210/pdb3hcc/pdb
Related	1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72 2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCD 3HCE 3HCF
Descriptor	Phenylethanolamine N-methyltransferase, (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywords	methyltransferase, catecholamine biosynthesis, polymorphism, s-adenosyl-l-methionine, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64915.21
Authors	Drinkwater, N.,Martin, J.L.,Gee, C.L.,Puri, M. (deposition date: 2009-05-06, release date: 2009-08-25, Last modification date: 2023-09-06)
Primary citation	Drinkwater, N.,Gee, C.L.,Puri, M.,Criscione, K.R.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L. Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Biochem.J., 422:463-471, 2009 Cited by PubMed: 19570037 DOI: 10.1042/BJ20090702 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation